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Home›Dermatology A–Z›Niacinamide

Ingredient

Niacinamide

Vitamin B3 derivative commonly used for barrier support, pigmentation and redness.

Dr Davin Lim, Dermatologist

Used for
Barrier · Pigmentation · Redness
Category
Vitamin B3 derivative
Form
Serums · Creams
Results
Progressive over weeks

In brief

What is it?

Niacinamide is a form of vitamin B3. Applied to skin, it supports the barrier that holds water in and irritants out, and reduces the transfer of pigment to the skin surface.

What is it best for?

Barrier repair →Pigmentation →Redness →Oily skin →

What does it actually do?

Strengthens the skin barrier
Reduces uneven pigmentation
Calms redness
Reduces oiliness

What Niacinamide will not do

Niacinamide will not remove established melasma by itself, dramatically remodel acne scars or replace appropriate prescription treatment when this is required.

In detail

The specifics, for patients who want them and for clinicians.

Using it

Ingredient
Common concentrations
2–5%; products up to 10%
How to use it
Once or twice daily, before moisturiser
Morning or evening
Either, or both
Combines with
Retinoids, azelaic acid, sunscreen, hyaluronic acid
Potential irritation
Low; flushing is possible at 10%
Who should be cautious
Very sensitive or rosacea-prone skin at high strength

What it does, and how well we know it

Strengthens the skin barrier Strong evidence

Increases ceramides and reduces water loss, so skin is less reactive.

Reduces uneven pigmentation Moderate evidence

Slows the transfer of pigment to the surface, softening marks over 8–12 weeks.

Calms redness Moderate evidence

Helps background redness, particularly where the barrier is weak.

Reduces oiliness Emerging evidence

A modest effect on sebum and the look of pores.

Risks and limitations

Flushing, warmth Uncommon

More likely at 10%. Drop to 2–5%.

Breakouts Rare

Usually from the product base rather than niacinamide itself.

Common questions about niacinamide

2 questions

Not usually. Most studies used 2–5%; 10% adds irritation more than benefit.

Yes. The old advice against combining it with vitamin C is outdated.

References

1

Hakozaki T, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol 2002;147(1):20–31.

2

Bissett DL, et al. Niacinamide: a B vitamin that improves aging facial skin appearance. Dermatol Surg 2005;31(7 Pt 2):860–865.

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