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Polynucleotides
Injectable biological molecules used primarily to improve skin quality.
Dr Davin Lim, Dermatologist
In brief
What is it?
Polynucleotides are purified fragments of DNA, usually from salmon or trout. Injected into the skin, they act as a scaffold and signal that support repair.
What is it best for?
What does it actually do?
What Polynucleotides will not do
Polynucleotides will not replace lost volume like filler, lift sagging skin, or correct deep acne scars on their own.
In detail
The specifics, for patients who want them and for clinicians.
The injection
InjectableWhat it does, and how well we know it
Firmer, more hydrated skin with finer texture.
Softens crepiness and fine lines where filler is less suitable.
Used between laser or needling sessions to support healing.
Risks and limitations
At each injection point, for 24–48 hours.
Especially under the eyes.
Tell me if you are allergic to fish.
Common questions about polynucleotides
2 questionsReferences
Lee KWA, et al. Polynucleotides in aesthetic medicine: a review of current practices and perceived effectiveness. Int J Mol Sci 2024;25(15):8224.
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Procedures, technique, before and afters, and the reasoning behind them — posted across three accounts, each with its own focus.